Substance Designer 5.2.0 build 16375 OSX

Just Drag the Substance Designer into Applications and replace the 'designer' with the on in Substance Designer. You my Chmod the thing to 755.

Like so:

chmod 755 /Applications/Substance\ Designer.app/Contents/MacOS/designer

note: I had it tested in El Capitan... it starts only when you start the designer via terminal like so:

/Applications/Substance\ Designer.app/Contents/MacOS/designer